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首页> 外文OA文献 >Involvement of nucleus accumbens dopamine D1 receptors in ethanol drinking, ethanol-induced conditioned place preference, and ethanol-induced psychomotor sensitization in mice
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Involvement of nucleus accumbens dopamine D1 receptors in ethanol drinking, ethanol-induced conditioned place preference, and ethanol-induced psychomotor sensitization in mice

机译：伏伏核多巴胺D1受体参与小鼠饮酒，乙醇诱导的条件性位置偏爱和乙醇诱导的精神运动敏化

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Rationale: Dopamine D1 receptor (D1R) signaling has been associated to ethanol consumption and reward in laboratory animals.Objectives: Here, we hypothesize that this receptor, which is located within the nucleus accumbens (NAc) neurons, modulates alcohol reward mechanisms.Methods: To test this hypothesis, we measured alcohol consumption and ethanol-induced psychomotor sensitization and conditioned place preference (CPP) in mice that received bilateral microinjections of small interference RNA (siRNA)-expressing lentiviral vectors (LV-siD1R) producing D1R knock-down. The other group received control (LV-Mock) viral vectors into the NAc.Results: There were no differences in the total fluid consumed and also no differences in the amount of ethanol consumed between groups prior to surgery. However, after surgery, the LV-siD1R group consumed less ethanol than the control group. This difference was not associated to taste neophobia. In addition, results have shown that down-regulation of endogenous D1R using viral-mediated siRNA in the NAc significantly decreased ethanol-induced behavioral sensitization as well as acquisition, but not expression, of ethanol-induced place preference.Conclusions: We conclude that decreased D1R expression into the NAc led to reduced ethanol rewarding properties, thereby leading to lower voluntary ethanol consumption. Together, these findings demonstrate that the D1 receptor pathway within the NAc controls ethanol reward and intake.
机译：原理：多巴胺D1受体（D1R）信号与实验室动物的乙醇消耗和奖励有关。目的：在这里，我们假设该受体位于伏伏核（NAc）神经元内，可调节酒精奖励机制。为了检验这一假设，我们在接受了产生D1R敲低的表达小干扰RNA（siRNA）的慢病毒载体（LV-siD1R）的双边显微注射的小鼠中测量了酒精消耗和乙醇诱导的精神运动敏化和条件性位置偏爱（CPP）。另一组在NAc中接受了对照（LV-Mock）病毒载体。结果：术前两组之间所消耗的总液体没有差异，所消耗的乙醇量也没有差异。但是，手术后，LV-siD1R组消耗的乙醇比对照组少。这种差异与味道恐惧症无关。此外，结果表明，在NAc中使用病毒介导的siRNA下调内源性D1R显着降低了乙醇诱导的行为敏化以及获得但不表达乙醇诱导的位置偏好。 D1R表达到NAc中导致乙醇奖励特性降低，从而导致自愿性乙醇消费量降低。总之，这些发现表明，NAc中的D1受体途径控制着乙醇的奖励和摄入。

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